Lu D, He A, Tan M, Mrad M, El Daibani A, Hu D, Liu X, Kleiboeker B, Che T, Hsu FF, Bambouskova M, Semenkovich CF, Lodhi IJ (2024). Liver ACOX1 Regulates Levels of Circulating Lipids that Promote Metabolic Health through Adipose Tissue Remodeling. Nature Communications 17;15(1):4214. PubMed

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Hammoud S, Ivanova A, Osaki Y, Funk S, Yang H, Viquez O, Delgado R, Lu D, Mignemi MP, Tonello J, Colon S, Lantier L, Wasserman D, Humphreys BD, Koenitzer J, Kern J, de Caestecker M, Finkel T, Fogo A, Messias N, Lodhi IJ, Gewin L (2024). Tubular CPT1A Deletion Minimally Affects Kidney Aging and Chronic Kidney Injury. JCI Insight 9(6): e171961. Pubmed

 

Kleiboeker B, He A, Tan M, Lu D, Hu D, Liu X, Goodarzi P, Hsu FF, Razani B, Semenkovich CF, Lodhi IJ (2024). Adipose Tissue Peroxisomal Lipid Synthesis Orchestrates Obesity and Insulin Resistance through LXR-Dependent Lipogenesis. Molecular Metabolism 82:101913.

PubMed

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Zhang X, Kapoor D, Jeong SJ, Fappi A, Stitham J, Shabrish V, Sergin I, Yousif E, Rodriguez-Velez A, Yeh YS, Park A, Yurdagul A Jr, Rom O, Epelman S, Schilling JD, Sardiello M, Diwan A, Cho J, Stitziel NO, Javaheri A, Lodhi IJ, Mittendorfer B, Razani B (2024). Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk. Nature Metabolism. Feb;6(2):359-377. PubMed

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Hu D, Tan, M, Lu D, Kleiboeker, Liu X, Park H, Kravitz AV, Shoghi KI, Tseng YH, Razani B, Ikeda A, Lodhi IJ (2023). TMEM135 Links Peroxisomes to the Regulation of Brown Fat Mitochondrial Fission and Energy Homeostasis. Nature Communications. Sep 29;14(1):6099. PubMed

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Zhang X, Evans TD, Chen S, Sergin I, Stitham J, Jeong SJ, Rodriguez-Velez A, Yeh YS, Park A, Jung IH, Diwan A, Schilling JD, Rom O, Yurdagul A, Epelman S, Cho J, Lodhi IJ, Mittendorfer B, Razani B (2023). Loss of Macrophage mTORC2 Drives Atherosclerosis via FoxO1 and IL-1β Signaling. Circulation Research. 133(3):200-219. PubMed

 

Lodhi IJ, editor. Thermogenic Fat: Methods and Protocols (Methods in Molecular Biology book series). New York, NY, Springer Nature; 2023. 253 pages. Download

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Lu D, Fujiwara H, Lodhi IJ, Hsu FF (2023). Isolation and Mass Spectrometry-Based Profiling of Major Lipids in Brown Adipose Tissue. Methods in Molecular Biology 2662:219-239.  PubMed 

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Hu D and Lodhi IJ (2023). Thermogenic Phenotyping in Mice. Methods in Molecular Biology. 2662:117-124. PubMed

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Johnson JM, Peterlin AD, Balderas E, Sustarsic EG, Maschek JA, Lang MJ, Jara-Ramos A, Panic V, Morgan JT, Villanueva CJ, Sanchez A, Rutter J, Lodhi IJ, Cox JE, Fisher-Wellman KH, Chaudhuri D, Gerhart-Hines Z, Funai K (2023). Mitochondrial phosphatidylethanolamine modulates UCP1 to promote brown adipose thermogenesis. Science Advances 9(8): eade7864. PubMed

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Kleiboeker B and Lodhi IJ (2022). Peroxisomal Regulation of Energy Homeostasis: Effect on Obesity and Related Metabolic Disorders. Molecular Metabolism 65:101577. Full-text

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Zhang X, Misra SK, Moitra P, Zhang X, Jeong SJ, Stitham J, Rodriguez-Velez A, Park A, Yeh YS, Gillanders WE, Fan D, Diwan A, Cho J, Epelman S, Lodhi IJ, Pan D, Razani B (2022). Use of Acidic Nanoparticles to Rescue Macrophage Lysosomal Dysfunction in Atherosclerosis. Autophagy. 18: 1-18. Published online ahead of print August 18, 2022. PubMed

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Ding L, Sun W, Balaz M, He A, Klug M, Wieland S, Caiazzo R, Raverdy V, Pattou F, Lefebvre P, Lodhi IJ, Staels B, Heim M, Wolfrum C (2021). Peroxisomal Beta-Oxidation Acts as a Sensor for Intracellular Fatty Acids and Regulates Lipolysis. Nature Metabolism 3(12):1648-1661. PubMed

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Spears LD, Adak S, Dong G, Wei X, Spyropoulos G, Zhang Q, Yin L, Feng C, Hu D, Lodhi IJ, Hsu FF, Rajagopal R, Noguchi KK, Halabi CM, Brier L, Bice AR, Lananna BV, Musiek ES, Avraham O, Cavalli V, Holth JK, Holtzman DM, Wozniak DF, Culver JP, Semenkovich CF (2021). Endothelial ether lipids link the vasculature to blood pressure, behavior, and neurodegeneration. Journal of Lipid Research. ePub ahead of print April 21, 2021. PubMed

 

Jeong SJ, Stitham J, Evans TD, Zhang X, Rodriguez-Velez A, Yeh YS, Tao J, Takabatake K, Epelman S, Lodhi IJ, Schilling JD, DeBosch BJ, Diwan A, Razani B (2021). Trehalose causes low-grade lysosomal stress to activate TFEB and the autophagy-lysosome biogenesis response. Autophagy. ePub ahead of print March 11, 2021. PubMed

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He A, Dean JD, Lodhi IJ (2021). Peroxisomes as Cellular Adaptors to Metabolic and Environmental Stress. Trends in Cell Biology. ePub ahead of print March 2, 2021. PubMed

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Dean JM, He A, Tan M, Wang J, Lu D, Razani B, Lodhi IJ (2020) . MED19 Regulates Adipogenesis and Maintenance of White Adipose Tissue Mass by Mediating PPARg-Dependent Gene Expression. Cell Reports 33(1):108228. PubMed

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He A, Dean JD, Lu D, Chen Y, Lodhi IJ (2020). Hepatic peroxisomal beta-oxidation suppresses lipophagy via RPTOR acetylation and MTOR activation. Autophagy 16(9):1727-1728. PubMed

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Li, LY, Li JM, Ning LJ, Lu D, Luo Y, Ma Q, Limbu SM, Li D, Chen LQ, Lodh IJ, Degrace P, Zhang ML, Du ZY (2020). Mitochondrial Fatty Acid β-Oxidation Inhibition Promotes Glucose Utilization and Protein Deposition through Energy Homeostasis Remodeling in Fish.

Journal of Nutrition 150(9):2322-2335. PubMed

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He A, Chen X, Tan M, Chen Y, Lu D, Zhang X, Dean JD, Razani B, Lodhi IJ (2020). Acetyl-CoA Derived from Hepatic Peroxisomal Beta-Oxidation Inhibits Autophagy and Promotes Steatosis via mTORC1 Activation. Molecular Cell 79(1):30-42. PubMed

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Zhang X, Sergin I, Evans TD, Jeong S, Rodriguez-Velez A, Kapoor D, Chen S, Song E, Holloway KB, Crowley JR, Epelman S, Weihl CC, Diwan A, Fan D, Mittendorfer B, Stitziel NO, Schilling JD, Lodhi IJ, Razani B (2020). High-protein diets increase cardiovascular risk by activating macrophage mTOR to suppress mitophagy. Nature Metabolism 2(1):110-125. PubMed

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Johnson JM, Verkerke ARP, Maschek JA, Ferrara PJ, Lin CT, Kew KA, Neufer PD, Lodhi IJ, Cox JE, Funai K (2020). Alternative splicing of UCP1 by non-cell-autonomous action of PEMT. Molecular Metabolism 31:55-66.  PubMed

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Evans TD, Zhang X, Jeong SJ, He A, Bhattacharya S, Song E, Holloway KB, Lodhi IJ, Razani B (2019). TFEB drives Adipocyte PGC-1α to protect against Diet-Induced Metabolic Dysfunction.  Science Signaling 12(606): eaau2281. DOI: 10.1126/scisignal.aau228

PubMed

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Park H, He A, Lodhi IJ (2019). Lipid Regulators of Thermogenic Fat Activation. Trends in Endocrinology & Metabolism 30(10): 710-723.

PubMed

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Park H*, He A*, Tan M, Dean JM, Johnson JM, Chen Y,Zhang X, Hsu FF, Razani B, Funai F, and Lodhi IJ (2019). Peroxisome-Derived Lipids Regulate Adipose Thermogenesis by Mediating Cold-Induced Mitochondrial Fission. Journal of Clinical Investigation 129(2):694-711. *Co-first authors. PubMed

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Dean JM and Lodhi IJ (2018). Structural and Functional Roles of Ether Lipids. Protein & Cell 9(2):196-206. PubMed

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Cipolla CM and Lodhi IJ (2017). Peroxisomal Dysfunction in Age-Related Diseases. Trends in Endocrinology & Metabolism 28(4): 297-308. PubMed

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Lodhi IJ#, Dean JM, He A, Park H, Tan M, Feng C, Song H, Hsu FF, Semenkovich CF (2017). PexRAP Inhibits PRDM16-Mediated Thermogenic Gene Expression. Cell Reports 20: 2766–2774. #Corresponding author.  PubMed

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Guilherme A, Pederson DJ, Henchey E, Henriques FS, Danai LV, Shen Y, Yenilmez B, Jung DY, Kim JK, Lodhi IJ, Semenkovich CF, and Czech MP (2017). Adipocyte lipid synthesis coupled to neuronal control of thermogenic programming. Molecular Metabolism 6(8): 781-796.

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Klionsky DJ et al. (2016). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd Edition). Autophagy 12(1): 1-222. PMCID: PMC4835977.

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Funai K*, Lodhi IJ*, Spears LD, Yin L, Song H, Klein S, and Semenkovich CF (2016). Skeletal Muscle Phospholipid Metabolism Regulates Insulin Sensitivity and Contractile Function. Diabetes 65(2):358-70. PMCID: PMC4747455

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Lodhi IJ, Link DC, and Semenkovich CF (2015). Acute ether lipid deficiency affects neutrophil biology in mice. Cell Metabolism 21(5): 652-3.  PMID: 25955199.

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Lodhi IJ, Wei X, Yin L, Feng C, Adak S, Abou-Ezzi G, Hsu FF, Link DC, and Semenkovich CF (2015). Peroxisomal lipid synthesis regulates inflammation by sustaining neutrophil membrane phospholipid composition and viability. Cell Metabolism 21(1):51-64. PMCID: PMC4287274.

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Lodhi IJ# and Semenkovich CF (2014).  Peroxisomes: A nexus for lipid metabolism and cellular signaling. Cell Metabolism 19(3): 380-392. (#Corresponding author). PMCID:  PMC395160

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Hsu FF, Lodhi IJ, Turk J, and Semenkovich CF (2014). Structural distinction of diacyl-, alkylacyl, and alk-1-enylacyl glycerophosphocholines as [M - 15]- ions multiple-stage linear ion-trap mass spectrometry with electrospray ionization. Journal of the American Society for Mass Spectrometry. 25(8):1412-20. PMID: 24781459 (PMCID: PMC4331342).

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Jensen-Urstad AP, Song H, Lodhi IJ, Funai K, Yin L, Coleman T, and Semenkovich CF (2013). Nutrient-dependent phosphorylation channels lipid synthesis to regulate PPARa.   Journal of Lipid Research 54(7):1848-1859. PMCID: PMC3679387

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Funai K, Song H, Yin L, Lodhi IJ, Wei X, Yoshino J, Coleman T, and Semenkovich CF (2013). Muscle lipogenesis balances insulin sensitivity and strength through calcium signaling. Journal of Clinical Investigation 123(3):1229-1240. PMCID: PMC3582136

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Lodhi IJ, Yin L, Jensen-Urstad AP, Funai K, Coleman T, Baird JH, El Ramahi MK, Razani B, Song H, Fu-Hsu F, Turk J, and Semenkovich CF (2012). Inhibiting adipose tissue lipogenesis reprograms thermogenesis and PPARg activation to decrease diet-induced obesity.

Cell Metabolism 16(2): 189-201. PMCID: PMC3467338.

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Lodhi IJ, Wei, X, and Semenkovich CF (2011).  Lipoexpediency: De Novo lipogenesis as a metabolic signal transmitter.

Trends in Endocrinology and Metabolism 22(1): 1-8.  PMCID:  PMC3011046

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Razani B, Zhang H, Schulze PC, Schilling JD, Verbsky J, Lodhi IJ, Topkara VK, Feng C, Coleman T, Kovacs A, Kelly DP, Saffitz JE, Dorn GW, Nichols CG, and Semenkovich CF (2011). Fatty acid synthase modulates homeostatic responses to myocardial stress. Journal of Biological Chemistry 2286 (35): 30949-30961. PMCID: PMC3162454

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Schneider JG, Yang Z, Chakravarthy MV, Lodhi IJ, Wei X, Turk J, and Semenkovich CF (2010).  Macrophage fatty acid synthase deficiency decreases diet-induced atherosclerosis. Journal of Biological Chemistry 285 (30): 23398-23409. PMCID:  PMC2906331

           

Chakravarthy MV*, Lodhi IJ*, Yin L, Malapaka RV, Xu HE, Turk J, and Semenkovich CF (2009). Identification of a physiologically relevant endogenous ligand for PPARa in liver. Cell 138 (3): 476-488. PMCID:  PMC2725194. *Co-first authors

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Lodhi IJ and Semenkovich CF (2009).  Why we should put clothes on mice.  Cell Metabolism 9(2): 111-112. PMID:  19187768.

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Lodhi IJ*, Bridges D*, Chiang SH, Zhang Y, Cheng A, Geletka LM, Weisman LS, and Saltiel AR (2008).  Insulin stimulates phosphatidylinositol 3-phosphate production via the activation of Rab5.  Molecular Biology of the Cell 19(7): 2718-2728. PMCID:  PMC2441665

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Lodhi IJ, Chiang SH, Chang L, Vollenweider D, Watson RT, Inoue, M, Pessin JE, and Saltiel AR (2007). Gapex-5, a Rab31 Guanine nucleotide exchange factor that regulates Glut4 trafficking in adipocytes. Cell Metabolism 5(1): 59-72.  PMCID:  PMC1779820

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Su, X, Lodhi IJ, Saltiel AR, and Stahl, PD (2006).  Insulin-stimulated interaction between insulin receptor substrate 1 and p85alpha and activation of protein kinase b/akt require rab5.  Journal of Biological Chemistry 281(38): 27982-27990.  PMID: 16880210.