The Lodhi Lab studies how peroxisomal lipid metabolism shapes cellular and whole-body physiology. Our research focuses on the emerging roles of peroxisomes as metabolic signaling organelles and their interactions with mitochondria and other cellular compartments. We seek to uncover how specialized lipid pathways regulate thermogenesis, energy balance, and metabolic health, and how disruption of these pathways contributes to obesity, diabetes, fatty liver disease, and cardiovascular disease. By integrating molecular and cellular approaches with lipidomics, genetic models, and metabolic physiology, we aim to discover fundamental mechanisms of metabolism with the potential to reveal new strategies for treating metabolic disease.